1. WHO WANTS TO LIVE FOREVER?

    By Heather Farmbrough. Autumn 2019
    Photography by Chris Close.
  2. Ageing and death are unavoidable, but science is teaching us more about why and how we age. Author Sue Armstrong discusses the implications with Heather Farmbrough.

     

    This article originally featured in Baillie Gifford’s Autumn 2019 issue of Trust magazine.

  3. I met Sue Armstrong, the author of Borrowed Time, The Science of How and Why We Age, in the Royal Botanic Garden in Edinburgh, in the memorial garden dedicated to Queen Elizabeth The Queen Mother. That lady knew a thing or two about ageing well.

    But here’s the thing – we are all getting older, all of the time, some of us faster than others, thanks to our cells. In Borrowed Time, Armstrong, a writer, science broadcaster and former foreign correspondent, tells a compelling story of the scientific discoveries and efforts to help prevent or delay some of the more serious aspects of ageing. In passing, she solves a few everyday mysteries such as why we forget words and why cuts take longer to heal as we get older.

    What made her write this book, now? “This is a massive issue for policy makers, and the economy, and it is becoming more important,” she replies. “As soon as I tuned into the idea, I realised that I was hearing something about ageing almost every day. And it’s almost always full of angst. People are asking, what are we going to do about the ageing population?

    “When you look at the statistics they are worrying. The fastest growing segment of the population is people over 85 years old – it’s increasing five times as fast as those below the age of 65 – so the world’s population is changing dramatically and all our care systems are overstretched.”

    Her interest in ageing was also sparked by the fact that it happens to all of us. “Here’s me, on the threshold of old age,” she says, “I’m aware that there are dramatic changes going on deep inside me, and I’ve always wanted to understand such things. Knowledge is power.

    “It really hit me to discover that the biggest single risk factor for all those diseases we associate with old age, all those things we fear – dementia, heart trouble, stroke, osteoporosis, arthritis, cancer, diabetes – is quite simply the ageing process itself,” she continues. “If we recognise this, and we can understand how the process works, we can possibly intervene in the earlier stages to help prevent or delay the development of these distressing conditions. And yet neither the policy makers nor the NHS seem to have cottoned on to this.”

    Armstrong is critical of the tendency to spend millions of pounds trying to understand individual pathologies and find therapies, while neglecting the root causes of these illnesses. While she dismisses miracle cures, she does as much as she can to stay healthy.

    A slim, elegant 68-year-old, she keeps fit, walks as much as she can and sits down as little as possible, doesn’t eat junk food and tries to eat early in the evening and to get as much sleep as possible, although doesn’t always succeed with the last two.

    Armstrong has been writing and broadcasting since 1980, her career encompassing the beginning of the AIDS epidemic, a subject which she wrote about and whose effects she saw at first hand, particularly over a decade living in South Africa during the collapse of apartheid. Her previous book published in 2014, p53: The Gene that Cracked the Cancer Code, described the work of scientists in identifying key factors in the chain of events that can lead to cancer when the tumour-suppressor gene p53 stops working properly.

    This took Armstrong into the complex world of cellular senescence, which plays a particularly important role in ageing and in developing serious illness. Our cells are designed to divide in order to grow and repair our bodies. Dividing cells have a finite life; they don’t die, but they senesce. Usually the immune system gets rid of them but as we age, our immune system becomes weaker, so dysfunctional senescent cells accumulate. These leach substances into our collagen fibres, causing wrinkles and the exterior signs of ageing, as well as problems at a deeper level.

    How close are we to using some of the discoveries in Armstrong’s book to develop effective treatments? Cell senescence, she answers, is a prime target for ameliorating ageing, and there is some very exciting science going on in this field.

    Indeed, Unity Biotechnology, in which Scottish Mortgage Investment Trust and Edinburgh Worldwide Investment Trust are investors, is developing therapies aimed at selectively eliminating senescent cells to stop, slow or reverse age-associated diseases and restore tissue to a more functionally healthy state.

    However, as Armstrong warns, cellular biology is a delicate and complex science. “There is always a balance to be struck – many genes and their proteins have both Jekyll and Hyde roles. People like to think ‘oh we have found the gene for such and such’ but it is never as simple as that because genes are switched on in some circumstances and not others, and can be switched on in the wrong place.”

    For instance, p53 has several roles. “Unlike in cars, where things don’t talk to each other, in biology everything is talking to everything else and adjusts itself according to the messages it receives,” she adds. “If you just pick out one thing, you upset the whole equilibrium.”

    Armstrong offers a clear and readable explanation of the ageing process, both in person and in print. With similarly little fuss, at the end of our interview, while everyone else departs by car or taxi, she announces that she has enough time to walk, and sets off at a brisk pace towards the Water of Leith.

     

    Sue Armstrong appeared at the Scottish Mortgage-sponsored event Borrowed Time at the Baillie Gifford Borders Book Festival.

  4. The long history of ageing theory

    Theories about why and how we age are themselves as old as the hills. Aristotle believed that ageing was the result of the organs gradually cooling, while the ancient Chinese believed it was the consequence of imbalance, or the loss of a vital fluid stored in the kidneys. Yoga, meditation and essential oils have all evolved from Indian beliefs concerning the preservation of a sound body and mind.


    Aristotle, Greek philosopher, student of Plato and teacher of Alexander the Great.

    In the late 19th century, August Weismann, a German biologist, suggested the body’s cells take the brunt of life’s damage and once the body has matured and reproduced, it starts to decline, possibly for evolutionary reasons. In 1954, American biochemist Denham Harman came up with the free radical theory of ageing, also known as oxidative damage theory, involving atoms that become unstable inside our cells.

    A few years later, Nobel Prize-winning biologist Peter Medawar suggested that harmful, late-acting genetic mutations lead to ageing and cause illnesses such as Huntington’s disease and Familial Alzheimer’s.

    Modern ageing theory has evolved with our growing understanding of genetics.

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    The views expressed in this article should not be considered as advice or a recommendation to buy, sell or hold a particular investment. The article contains information and opinion on investments that does not constitute independent investment research, and is therefore not subject to the protections afforded to independent research.

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    AUTHOR: HEATHER FARMBROUGH

    Heather is a freelance journalist for several publications including The Telegraph and Forbes.com. She is a broadcaster and author, and used to be a fund manager.